By Sally Nicholls
A perilous contagion races via England...
Isabel and her kin have nowhere to run from a illness that has killed 1/2 Europe. whilst the area she understands and loves ends without end, her in simple terms weapon is courage.
The Black dying of 1349 was once the deadliest plague in human background. All Fall Down is a strong and encouraging tale of survival within the face of actual lifestyles horror.
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Additional resources for All Fall Down
1995). §. 300 I Ol ~... 1/1 CII I ~ y +l 1 Y Iy I I r 1:1 CII c :c 100 E 0 0 0 0 200 400 600 Age (days) Fig. 13. Combined testicular weight of knockout (closed circles) and control mice (open circles) compared in nine age-groups Cognitive functioning was measured in the Morris water maze test. In this test, the mice have to rely on their visual/spatial abilities to learn to find an invisible platform submerged in a circular basin filled with opaque water (Morris 1984). Fragile X patients have been reported to be deficient in visual/spatial abilities and visual short-term memory (Theobald et a1.
11). The first model suggested expansion of the repeat during maternal meiosis, with regression of the repeat during male germ cell formation. A se- Model 1 Model 2 Expansion ...... Oocyte :::J Oocyte yzygote (Regression) Oocytes Sperm cells ~selection 9 Mitotic instability •t • Somatic cells Gametic cells tE t m • • Somatic cells ~ Fig. 11. Schematic depiction of the two models for the timing of repeat amplification. Somatic cells are represented by circles, germ cells by squares. Closed symbols indicate cells with a full mutation, whereas open symbols represent cells containing a premutation 26 R.
1987; Kemper et a1. 1988a, b; Cianchetti et a1. 1991; Mazzocco et a1. 1993; Maes et a1. 1994; Bennetto and Pennington 1996). In 12 successive training sessions, the fragile X mice learned to find the hidden platform as well as the controls, although the rate of learning was marginally reduced (Fig. 14). More drastic differences were observed in the so-called reversal of the test, when the platform was placed in the opposite quadrant of the pool after the training sessions. Fragile X mice needed significantly more time to find the platform in its new position than the control littermates in all four reversal sessions (Bakker et al.